| English Premier League |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 16-Aug-09 | H | Liverpool | W | 2-1 | (1-0) | Assou-Ekotto 44; Bassong 59 | 35,935 |
| 2 | 19-Aug-09 | A | Hull City | W | 5-1 | (3-1) | Defoe 10, 45, 90; Palacios 14; Keane 78 | 24,735 |
| 3 | 23-Aug-09 | A | West Ham United | W | 2-1 | (0-0) | Defoe 54; Lennon 79 | 33,095 |
| 4 | 29-Aug-09 | H | Birmingham City | W | 2-1 | (0-0) | Crouch 72; Lennon 90 | 35,318 |
| 5 | 12-Sep-09 | H | Manchester United | L | 1-3 | (1-2) | Defoe 1 | 35,785 |
| 6 | 20-Sep-09 | A | Chelsea | L | 0-3 | (0-1) | | 41,623 |
| 7 | 26-Sep-09 | H | Burnley | W | 5-0 | (2-0) | Keane 18p, 74, 77, 87; Jenas 33 | 35,462 |
| 8 | 03-Oct-09 | A | Bolton Wanderers | D | 2-2 | (1-1) | Kranjcar 34; Corluka 73 | 21,305 |
| 9 | 17-Oct-09 | A | Portsmouth | W | 2-1 | (2-0) | King 29; Defoe 45 | 20,821 |
| 10 | 24-Oct-09 | H | Stoke City | L | 0-1 | (0-0) | | 36,031 |
| 11 | 31-Oct-09 | A | Arsenal | L | 0-3 | (0-2) | | 60,103 |
| 12 | 07-Nov-09 | H | Sunderland | W | 2-0 | (1-0) | Keane 12; Huddlestone 68 | 35,955 |
| 13 | 22-Nov-09 | H | Wigan Athletic | W | 9-1 | (1-0) | Crouch 9; Defoe 51, 54, 58, 69, 87; Lennon 64; Bentley 88; Kranjcar 90 | 35,650 |
| 14 | 28-Nov-09 | A | Aston Villa | D | 1-1 | (0-1) | Dawson 77 | 39,866 |
| 15 | 06-Dec-09 | A | Everton | D | 2-2 | (0-0) | Defoe 47; Dawson 59 | 34,003 |
| 16 | 12-Dec-09 | H | Wolverhampton Wndrs | L | 0-1 | (0-1) | | 36,012 |
| 17 | 16-Dec-09 | H | Manchester City | W | 3-0 | (1-0) | Kranjcar 37, 90; Defoe 54 | 35,891 |
| 18 | 19-Dec-09 | A | Blackburn Rovers | W | 2-0 | (1-0) | Crouch 45, 83 | 26,490 |
| 19 | 26-Dec-09 | A | Fulham | D | 0-0 | (0-0) | | 25,679 |
| 20 | 28-Dec-09 | H | West Ham United | W | 2-0 | (1-0) | Modric 11; Defoe 81 | 35,994 |
| 21 | 16-Jan-10 | H | Hull City | D | 0-0 | (0-0) | | 35,729 |
| 22 | 20-Jan-10 | A | Liverpool | L | 0-2 | (0-1) | | 42,016 |
| 23 | 26-Jan-10 | H | Fulham | W | 2-0 | (1-0) | Crouch 27; Bentley 60 | 35,467 |
| 24 | 30-Jan-10 | A | Birmingham City | D | 1-1 | (0-0) | Defoe 69 | 27,238 |
| 25 | 06-Feb-10 | H | Aston Villa | D | 0-0 | (0-0) | | 35,899 |
| 26 | 10-Feb-10 | A | Wolverhampton Wndrs | L | 0-1 | (0-1) | | 27,992 |
| 27 | 21-Feb-10 | A | Wigan Athletic | W | 3-0 | (1-0) | Defoe 27; Pavlyuchenko 84, 90 | 16,165 |
| 28 | 28-Feb-10 | H | Everton | W | 2-1 | (2-0) | Pavlyuchenko 11; Modric 28 | 35,912 |
| 29 | 13-Mar-10 | H | Blackburn Rovers | W | 3-1 | (1-0) | Defoe 45; Pavlyuchenko 55, 85 | 35,474 |
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|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 02-Jan-10 | H | Peterborough United | W | 4-0 | (1-0) | Kranjcar 35, 57; Defoe 70; Keane 90p | 35,862 |
| 4 | 23-Jan-10 | H | Leeds United | D | 2-2 | (1-0) | Crouch 42; Pavlyuchenko 75 | 35,750 |
| 4r | 03-Feb-10 | A | Leeds United | W | 3-1 | (1-1) | Defoe 37, 73, 90 | 37,704 |
| 5 | 14-Feb-10 | A | Bolton Wanderers | D | 1-1 | (0-1) | Defoe 61 | 13,596 |
| 5r | 24-Feb-10 | H | Bolton Wanderers | W | 4-0 | (2-0) | Pavlyuchenko 23, 87; Jaaskelainen(og) 35; O'Brien(og) 47 | 31,436 |
| QF | 06-Mar-10 | A | Fulham | D | 0-0 | (0-0) | | 24,533 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 2 | 26-Aug-09 | A | Doncaster Rovers | W | 5-1 | (3-0) | Huddlestone 9; O'Hara 11; Crouch 37; Bentley 52; Pavlyuchenko 69 | 12,923 |
| 3 | 23-Sep-09 | A | Preston North End | W | 5-1 | (2-0) | Crouch 14, 77, 90; Defoe 37; Keane 87 | 16,533 |
| 4 | 27-Oct-09 | H | Everton | W | 2-0 | (1-0) | Huddlestone 31; Keane 57 | 35,843 |
| QF | 01-Dec-09 | A | Manchester United | L | 0-2 | (0-2) | | 57,212 |
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Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.